Abai Region is a region of Kazakhstan. President Kassym-Jomart Tokayev announced on 16 March 2022 that the region would be created. The area split off from East Kazakhstan Region when Tokayev's bill came into force on 8 June 2022. The administrative center of the region is Semey, until 2007 known as Semipalatinsk. Its borders roughly correspond to the old Semipalatinsk Region which was liquidated in 1997 and merged with East Kazakhstan Region.

Kazakhstan is divided into 17 regions. The regions are further subdivided into districts. Three cities, Almaty, Shymkent, and the capital city Astana, do not belong to their surrounding regions.