Abdullah Khan (1533/4–1598), known as "The Old Khan", was an Uzbek ruler of the Khanate of Bukhara (1500–1785). He was the last uncontested Shaybanid Khan of Bukhara from 1583 until his death.

The Khanate of Bukhara was an Uzbek state in Central Asia from 1501 to 1785, founded by the Abu'l-Khayrid dynasty, a branch of the Shaybanids. From 1533 to 1540, Bukhara briefly became its capital during the reign of Ubaydallah Khan. The Khanate reached its greatest extent and influence under its penultimate Abu'l-Khayrid ruler, the scholarly Abdullah Khan II.