The Accademia Nazionale di Santa Cecilia is one of the oldest musical institutions in the world, founded by the papal bull Ratione congruit, issued by Sixtus V in 1585, which invoked two saints prominent in Western musical history: Gregory the Great, for whom the Gregorian chant is named, and Saint Cecilia, the patron saint of music. Since 2005 it has been headquartered at the Renzo Piano designed Parco della Musica in Rome.

Saint Cecilia, also spelled Cecelia, was a Roman virgin martyr and is venerated in Catholic, Orthodox, Anglican, and some Lutheran churches, such as the Church of Sweden. She became the patroness of music and musicians, it being written that, as the musicians played at her wedding, Cecilia "sang in her heart to the Lord". Musical compositions are dedicated to her, and her feast, on 22 November, is the occasion of concerts and musical festivals. She is also known as Cecilia of Rome.