Acetazolamide
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Acetazolamide, sold under the trade name Diamox among others, is a medication used to treat glaucoma, epilepsy, acute mountain sickness, periodic paralysis, idiopathic intracranial hypertension, and h
Proximal convoluted tubule. Urinary space is on left.
Carbonic anhydrase
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The carbonic anhydrases form a family of enzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid. The active site of most carbonic anhydras
Acetazolamide
…for acute angle closure glaucoma until surgery can be carried out. It is taken by mouth or injection into a vein. Acetazolamide is a first generation carbonic anhydrase inhibitor and it decreases the ocular fluid and osmolality in the eye to decrease intraocular pressure. Common side effects include numbness, ringing…
Active site of CAII enzyme (PDB code: 1CA2) which O = red, N = blue, Zn = grey and C = green
CAII enzyme (PDB code: 1CA2) showing the secondary structures and the hydrophobic pocket (right side of the Zn2+) formed by the beta sheet (blue) and the two valine and one tryptophan side chains
This image shows the ligands and pocket style of carbonic anhydrase.