Acetylcholinesterase
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Acetylcholinesterase acetylcholine acetylhydrolase, also known as AChase or acetylhydrolase, is the primary type of cholinesterase in the body, coded for in the human by the gene ACHE. It is an enzyme
PBB Protein ACHE image
AChe mechanism of action
1b41: HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH FASCICULIN-II, GLYCOSYLATED PROTEIN
1f8u: CRYSTAL STRUCTURE OF MUTANT E202Q OF HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH GREEN MAMBA VENOM PEPTIDE FASCICULIN-II
Sarin
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Sarin is an extremely toxic organophosphorus compound that has been often used as a chemical weapon due to its extreme potency as a nerve agent.
Acetylcholinesterase
…can become covalently bound. Irreversible AChE inhibitors have been used in insecticides (e.g., malathion) and nerve gases for chemical warfare (e.g., Sarin and VX). Carbamates, esters of N-methyl carbamic acid, are AChE inhibitors that hydrolyze in hours and have been used for medical purposes (e.g…
Rabbit used to check for leaks at former sarin production plant (Rocky Mountain Arsenal), 1970
U.S. Honest John missile warhead cutaway, showing M134 Sarin bomblets (c. 1960)