The Acqua Vergine is one of several Roman aqueducts that deliver pure drinking water to Rome. Its name derives from its predecessor Aqua Virgo, which was constructed by Marcus Vipsanius Agrippa in 19 BC. Its terminal castellum is located at the Baths of Agrippa, and it served the vicinity of Campus Martius through its various conduits. In an effort to restore fresh water to Rome during the Renaissance, Pope Nicholas V, in 1453, renovated the main channels of the Aqua Virgo and added numerous secondary conduits under Campo Marzio. The original terminus, called a mostra, which means showpiece, was the stately, dignified wall fountain designed by Leon Battista Alberti in Piazza dei Crociferi. Due to several additions and modifications to the end-most points of the conduits during the years that followed, during the Renaissance and Baroque periods, the Acqua Vergine culminated in several magnificent mostre - the Trevi Fountain and the fountains of Piazza del Popolo.

Leon Battista Alberti was an Italian Renaissance humanist author, artist, architect, poet, priest, linguist, philosopher, and cryptographer; he epitomised the nature of those identified now as polymaths. He is considered the founder of Western cryptography, a claim he shares with Johannes Trithemius.