Acquapendente is a city and comune in the province of Viterbo, in Lazio (Italy). Acquapendente is a centre for the agricultural production of vegetables and wine, and has a tradition of pottery craftsmanship. Its frazione of Torre Alfina is one of I Borghi più belli d'Italia.

I Borghi più belli d'Italia is a non-profit private association of small Italian towns of strong historical and artistic interest, that was founded in March 2001 on the initiative of the Tourism Council of the National Association of Italian Municipalities, with the aim of preserving and maintaining villages of quality heritage. Its motto is Il fascino dell'Italia nascosta.