Across 110th Street is a 1972 American neo noir action thriller film directed by Barry Shear and starring Yaphet Kotto, Anthony Quinn, Anthony Franciosa and Paul Benjamin. The film is set in Harlem, New York and takes its name from 110th Street, the traditional dividing line between Harlem and Central Park that functioned as an informal boundary of race and class in 1970s New York City.

Yaphet Frederick Kotto was an American actor for film and television. He starred in the NBC television series Homicide: Life on the Street (1993–1999) as Lieutenant Al Giardello. His films include the science-fiction horror film Alien (1979), the science-fiction action film The Running Man (1987), the James Bond film Live and Let Die (1973) in which he portrayed the main villain Dr. Kananga, and the action comedy Midnight Run (1988).