Across 110th Street is a 1972 American neo noir action thriller film directed by Barry Shear and starring Yaphet Kotto, Anthony Quinn, Anthony Franciosa and Paul Benjamin. The film is set in Harlem, New York and takes its name from 110th Street, the traditional dividing line between Harlem and Central Park that functioned as an informal boundary of race and class in 1970s New York City.

"Across 110th Street" is a single by Bobby Womack, from the soundtrack and film of the same name that starred Anthony Quinn and Yaphet Kotto.