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Active site
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In biology and biochemistry, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction. The active site consists of amino acid residues that form tempor
Hydrophobic and hydrophilic groups tend to assemble with the same kind of molecules.
Hydrophobic and hydrophilic groups tend to assemble with the same kind of molecules.
Indinavir, an HIV protease inhibitor.jpg
Indinavir, an HIV protease inhibitor.jpg
Denaturation (biochemistry)
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Process of partial or total alteration of the native secondary, and/or tertiary, and/or quaternary structures of proteins or nucleic acids resulting in a loss of bioactivity.
Active site
…these interactions are interfered with, for example by extreme pH values, high temperature or high ion concentrations, this will cause the enzyme to denature and lose its catalytic activity. A tighter fit between an active site and the substrate molecule is believed to increase the efficiency of a reaction…
Shifts in normal pH range result in denaturation of enzymes. Decreasing the pH results in interactions between protons and amino acids, resulting in t
Shifts in normal pH range result in denaturation of enzymes. Decreasing the pH results in interactions between protons and amino acids, resulting in the breakage of existing hydrogen bonds.
In a normal reaction, the substrate is able to bind to the active site to create the enzyme substrate complex, ultimately catalyzing a reaction. A den
In a normal reaction, the substrate is able to bind to the active site to create the enzyme substrate complex, ultimately catalyzing a reaction. A denatured enzyme changes the shape of the active site, which prevents the substrate from binding to the enzyme active site. The enzyme is unable to perform its function, therefore loss of function.
The enzyme depicted has an optimal pH of 8.3, so its reaction rate is the highest at this pH. Significantly increasing or decreasing this reaction's p
The enzyme depicted has an optimal pH of 8.3, so its reaction rate is the highest at this pH. Significantly increasing or decreasing this reaction's pH can cause this enzyme to denature and, subsequently, decrease the reaction rate.