Adrenochrome is a chemical compound produced by the oxidation of adrenaline (epinephrine). It was the subject of limited research from the 1950s through to the 1970s as a potential cause of schizophrenia. While it has no current medical application, the semicarbazide derivative, carbazochrome, is a hemostatic medication.

Fear and Loathing in Las Vegas: A Savage Journey to the Heart of the American Dream is a 1971 novel in the gonzo journalism style by Hunter S. Thompson. The book is a roman à clef, rooted in autobiographical incidents. The story follows its protagonist, Raoul Duke, and his attorney, Doctor Gonzo, as they descend on Las Vegas to chase the American Dream through a drug-induced haze, all the while ruminating on the failure of the 1960s countercultural movement. The work is Thompson's most famous book and is noted for its lurid descriptions of illicit drug use and its early retrospective on the culture of the 1960s. Thompson's highly subjective blend of fact and fiction, which it popularized, became known as gonzo journalism. Illustrated by Ralph Steadman, the novel first appeared as a two-part series in Rolling Stone magazine in 1971 before being published in book form in 1972. It was later adapted into a film of the same title in 1998 by director Terry Gilliam, starring Johnny Depp and Benicio del Toro, who portrayed Raoul Duke and Dr. Gonzo, respectively.