The Adriatic railway is the railway from Ancona to Lecce that runs along the Adriatic Coast of Italy, following it almost all of the way. It is one of the main lines of the Italian rail system and links the northern cities with the most important productive areas of central and southern Italy.

Lecce railway station serves the city and comune of Lecce, in the region of Apulia, Southern Italy. Opened in 1866, it is the southern terminus of the Adriatic Railway (Ancona–Lecce), and is also the terminus of two regional lines, the Martina Franca–Lecce railway and the Lecce–Otranto railway.