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Advent is a season of the liturgical year observed in many Christian churches as a time of expectant waiting and preparation for both the celebration of the Nativity of Jesus at Christmas and the return of Jesus at the Second Coming. Advent is the beginning of the Western liturgical year; the term "Advent" is used in Eastern Orthodoxy for the 40-day Nativity Fast, which has practices different from those in the West. The term adopted from Latin adventus "coming. In the New Testament, this is the term used for the Second Coming of Christ. Thus, the season of Advent in the Christian calendar anticipates the "coming of Christ" from three different perspectives: the physical nativity in Bethlehem, the reception of Christ in the heart of the believer, the eschatological Second Coming. In the Roman Rite of the Catholic Church, the Western Rite of the Orthodox Church, in the Anglican, Moravian and Methodist calendars, Advent commences on the fourth Sunday before Christmas—the Sunday nearest to St. Andrew's Day.

It can fall on any date between 3 December. When Christmas Day is a Monday, Advent Sunday will fall on its latest possible date. In the Ambrosian Rite and the Mozarabic Rite of the Catholic Church, Advent begins on the sixth Sunday before Christmas, the Sunday after St. Martin's Day. Practices associated with Advent include keeping an Advent calendar, lighting an Advent wreath, praying an Advent daily devotional, erecting a Christmas tree or a Chrismon tree, lighting a Christingle, as well as other ways of preparing for Christmas, such as setting up Christmas decorations, a custom, sometimes done liturgically through a hanging of the greens ceremony; the equivalent of Advent in Eastern Christianity is called the Nativity Fast, but it differs in length and observances, does not begin the liturgical church year as it does in the West. The Eastern Nativity Fast does not use the equivalent parousia in its preparatory services, it is not known when the period of preparation for Christmas, now called Advent first began – it was in existence from about 480 – and the novelty introduced by the Council of Tours of 567 was to order monks to fast every day in the month of December until Christmas.

It is "impossible to claim with confidence a credible explanation of the origin of Advent". Associated with Advent was a period of fasting, known as the Nativity Fast or the Fast of December. According to Saint Gregory of Tours the celebration of Advent began in the fifth century when the Bishop Perpetuus directed that starting with the feast of St. Martin, 11 November, until Christmas, one fasts three times per week; this practice remained limited to the diocese of Tours until the sixth century. But the Macon council held in 581 adopted the practice in Tours and soon all France observed three days of fasting a week from the feast of Saint Martin until Christmas; the most devout worshipers in some countries exceeded the requirements adopted by the Council of Macon, fasted every day of Advent. The homilies of Gregory the Great in the late sixth century showed four weeks to the liturgical season of Advent, but without the observance of a fast. However, under Charlemagne in the ninth century, writings claim that the fast was still observed.

In the thirteenth century, the fast of Advent was not practised although, according to Durand of Mende, fasting was still observed. As quoted in the bull of canonisation of St. Louis, the zeal with which he observed this fast was no longer a custom observed by Christians of great piety, it was limited to the period from Saint Andrew until Christmas Day, since the solemnity of this apostle was more universal than that of St. Martin; when Pope Urban V ascended the papal seat in 1362, he forced people in his court to abstinence but there was no question of fasting. It was customary in Rome to observe five weeks of Advent before Christmas; this is discussed in the Sacramentary of St. Gregory. Ambrosian or Milan Liturgies have six; the Greeks show no more real consistency. The liturgy of Advent remained unchanged until the Second Vatican Council, in 1963, introduced minor changes, differentiating the spirit of Lent from that of Advent, emphasising Advent as a season of hope for Christ's coming now as a promise of his Second Coming.

The theme of readings and teachings during Advent is the preparation for the Second Coming, while commemorating the First Coming of Christ at Christmas. The first clear references in the Western Church to Advent occur in the Gelasian Sacramentary, which provides Advent Collects and Gospels for the five Sundays preceding Christmas and for the corresponding Wednesdays and Fridays. While the Sunday readings relate to the first coming of Jesus Christ as saviour as well as to his Second Coming as judge, traditions vary in the relative importance of penitence and expectation during the weeks in Advent. Since the 13th century, the usual liturgical colour in Western Christianity for Advent has been violet; the violet or purple colour is used for hangings around the church, the vestments of the clergy, also the tabernacle. In some Christian denominations, blue, a colour representing hope, is an alternative liturgical colour for Advent, a custom traced to the usage of the Church of Sweden and the medieval Sarum Rite in England.

In addition, the colour blue is used

Airport Link, Brisbane

The Airport Link is a tunnelled, motorway grade, toll road in the northern suburbs of Brisbane, Australia. It connects the Brisbane central business district and the Clem Jones Tunnel to the East-West Arterial Road which leads to the Brisbane Airport, it was built in conjunction with the Windsor to Kedron section of the Northern Busway in the same corridor. The Airport Link and busway project involves 15 kilometres of tunnelling including the road, busway tunnels and connecting ramps, as well as 25 bridges and result in over 7 kilometres of new road; the Airport Link is Australia's longest road tunnel. The estimated construction cost of the Airport Link is $4.8 billion. The toll for the full length is $5.30 for a car. Construction of the Airport Link, Northern Busway and Airport Roundabout Upgrade projects were scheduled for completion in mid-2012. Following a preview walk on 15 July 2012 and final safety approvals, the Airport Link opened to the public at 11.55 pm on 24 July 2012. The contract was awarded to the consortium BrisConnections, composed of Macquarie Group and John Holland, beating two other consortia.

BrisConnections was announced as the preferred bidder on 19 May 2008, the final contract was awarded on 2 June 2008. Conducted as a public-private partnership, the financial aspects of the Airport Link project has been mired in controversy from the outset. Macquarie Group charged $110 million in fees for the financial engineering which used the equity from private investors to raise the necessary debt and planned to pay investor distributions from capital, an arrangement which resembles a Ponzi scheme and has been ridiculed as the "dead parrot model", after the famous Monty Python comedy sketch. Former Queensland Premier Anna Bligh enjoyed a free holiday at the Sydney mansion of Thiess director Ros Kelly just before the contract was awarded. Former Labor ministers Terry Mackenroth and Con Sciacca were paid a "success fee", believed to be about $500,000, by BrisConnections after the consortium won the tender. BrisConnections was listed as a unit trust on the Australian Securities Exchange via a $1.2 billion initial public offering of installment receipts on 31 July 2008.

This was the largest IPO in the most disastrous. The value of initial $1 installments fell by 60 per cent on the first day of trading, by late November had collapsed to 0.1c, the lowest possible price on the ASX. The dramatic price slide was due to the leverage risk associated with stapled securities. Among the institutional investors was the Queensland Investment Corporation, which invested $25 million; the chairman of QIC is Trevor Rowe, the Chairman of BrisConnections and was awarded Member of the Order of Australia in 2004 "for service to the investment banking sector and as a contributor to the formulation of public policy... and to the community."It is believed that some of this negative market sentiment was in response to the traffic forecasts contained within the Product Disclosure Statement lodged by BrisConnections. The EIS lodged by government showed traffic forecasts in 2012 of 95,000 vehicles per day, rising to 120,000 motorists by 2026; the Product Disclosure Statement prepared by PBA provides forecast of 193,000 vehicles in 2012 rising to 291,000 vehicles by 2026.

During the early period of the BrisConnections listing most of the securities were owned by institutional investors, however as the price collapsed many of these institutions divested their now worthless stock, including Macquarie Group. Most of these shares were taken up by retail investors who were unaware that two further $1 installments on the stapled securities were owing and faced financial ruin as a result. BrisConnections has threatened to sue these investors in order to raise the capital necessary to continue the project, while reducing dividends by 99 per cent. There are no further installments owning which means there are no further obligations on shareholders attached to the units. While promoting BrisConnections at their media event in April 2009, Premier Anna Bligh denied any responsibility for the fate of the "Mum and Dad" investors saying, "it is not the role of the Queensland Government to underwrite private investment decisions made by people who were seeking to make a profit investing in the stock market".

At this time, the Australian Securities and Investments Commission belatedly sought to act on behalf of investors and to seek an independent report of BrisConnections' finances. BrisConnections was nearly wound up in April 2009 after the private company of one investor, Nicholas Bolton, requisitioned a general meeting of members of the managing company. However, on the date of the meeting the proxies attached to Bolton's shares were exercised to against the resolutions, Bolton's company having earlier sold the proxy rights for $4.5 million to Theiss-John Holland Group and the contractor for the Airport Link project. Therefore, the special resolution fell short of the required 75% vote to pass and BrisConnections was allowed to continue operating under its current form. In May, 70% of outstanding shares defaulted on the second $1 instalment payment; some shareholders transferred their shares off market to false identities, such as Humphrey B. Bear, in order to avoid payment. An auction of shares in default failed to attract a bidder.

In June, BrisConnections commenced legal action to recover the unpaid moneys. With Brisconnections launching legal claims against defaulting investors, controversial businessman Jim Byrnes postured as a champion of small investors; the controversy featured prominently in Brisbane newspapers: The na

Minshull Vernon

Minshull Vernon is a hamlet and civil parish in the unitary authority of Cheshire East and the ceremonial county of Cheshire, England. The hamlet lies 3 miles to the north west of Crewe, south east of Winsford and south west of Middlewich; the parish includes the small settlements of Bradfield Green, Hoolgrave, Minshull Hill, Walley's Green and Weaver Bank. The total population of the civil parish is somewhat over 200, measured at 391 in the Census 2011. Nearby villages include Church Minshull and Wimboldsley; the River Weaver and the Middlewich Branch of the Shropshire Union Canal run through the area. A Roman road between Nantwich and Middlewich ran northwards through the civil parish. Minshull Vernon and the adjacent parish of Church Minshull appear in the Domesday survey as Maneshale, which formed part of the extensive lands of William Malbank and had a hawk's eyrie and four deer enclosures; the remains of two medieval moated sites provide evidence for settlement during that period. In the Tudor period, Minshull Vernon formed part of the lands of the Venable family, lords of Middlewich.

A description of the parish from the early 17th century records its spacious farms. There were three churches or chapels in the 19th century, Wesleyan Methodist and Church of England. In 1840, a school was built at Bradfield Green; the parish suffered bombing with two fatalities. Minshull Vernon is administered by Minshull Vernon and District Parish Council, jointly with Leighton and Woolstanwood. Of 22 parish councillors, seven represent Minshull Vernon. From 1974 the civil parish was served by Crewe and Nantwich Borough Council, succeeded on 1 April 2009 by the unitary authority of Cheshire East. Minshull Vernon falls in the parliamentary constituency of Eddisbury, represented by Edward Timpson since 2019, after being represented by Stephen O'Brien and Antoinette Sandbach; the civil parish has a total area of 2,736 acres. The area is flat, with an average elevation of around 50 metres; the civil parish is rural, with the major land use being agricultural, predominantly pasture. A short stretch of the River Weaver forms part of the northern boundary of the parish and Hoggins Brook runs along its eastern boundary.

The parish contains several areas of woodland, including Burnt Covert, Larch Wood, Spring Plantation, Worsley Covert and parts of Polestead Wood and Weaver Bank Wood. Two small areas in the north west and south west of the parish, together with the western parish boundary, fall within the Weaver Valley Area of Special County Value. An underground gas storage plant is located south of Hole House at SJ69636056; the A530 runs north–south through the parish. Moss Lane and the B5076 run east and southeast from the A530 at Bradfield Green towards Barrows Green. Cross Lane runs west from Brookhouse Lane/Eardswick Lane to Church Minshull; the Middlewich Branch of the Shropshire Union Canal runs through the north-west of the parish, forms the majority of the western boundary. Cross Lane crosses the canal via Minshullhill Bridge; the Crewe–Winsford railway line runs north–south through the parish to the east of the A530. The Weaver Way follows the Shropshire Union towpath, the Crewe and Nantwich Circular Walk loops through the parish, in part following the towpath.

In 2006, the total population of the civil parish was estimated as 240. The 2001 census recorded a population of 224, in 94 households; this is around 60% of the population of 1851. Minshull Vernon United Reformed Church is located at the junction of Cross Lane, Brookhouse Lane and Eardswick Lane. A Congregational Chapel, the grade-II-listed church dates from 1809–1810 and was altered in around 1880, it is in brown brick with Victorian stained-glass windows featuring ogee tracery. The Church of England parish church of St Peter, Leighton-cum-Minshull Vernon, on Middlewich Road north of Bradfield Green was founded in 1840; the present rock-faced building by John Matthews dates from 1847–1849 and has a bell-cote and lancet windows. Newfield Hall on Middlewich Road in Walley's Green is a red-brick mansion on a double pile plan which dates from the early 19th century; the west front is flanked by stone elephants bearing howdahs, which are believed to have come from Adderley Hall near Market Drayton in Shropshire.

A small red-brick summerhouse in the grounds, thought to have been a privy, has a slate roof topped with a ball finial. It dates from the same period as the hall, is listed at grade II. Hoolgrave Manor on Eardswick Lane is a grade-II-listed hall, now a farmhouse, in brown brick on a U-shaped plan. Dating from the late 17th century, it features brick pilasters at the corners and a central projecting bay with an oriel window and topped with a pediment. Eardswick Hall on Eardswick Lane is a grade-II-listed farmhouse which dates from 1849; the farmhouse, in Jacobean style, is in red brick with blue-brick d


Venetoclax, sold under the trade name Venclexta and Venclyxto, is a medication used to treat chronic lymphocytic leukemia. Venetoclax is used for adults with small lymphocytic lymphoma. Indication does not depend on mutation status. Venetoclax is used as part of a combination therapy for acute myeloid leukemia. For this purpose it is with azacitidine, decitabine, or low-dose cytarabine for newly-diagnosed adults over 75, or those with other health problems where intensive chemotherapy cannot be used. Common side effects of venetoclax include neutropenia, anemia, upper respiratory tract infection and thrombocytopenia. Major side effects include severe neutropenia. Additionally, this drug may cause fertility problems in males. Venetoclax is a BH3-mimetic. Venetoclax blocks the anti-apoptotic B-cell lymphoma-2 protein, leading to programmed cell death of CLL cells. Overexpression of Bcl-2 in some lymphoid malignancies has sometimes shown to be linked with increased resistance to chemotherapy; the maximum plasma concentration achieved.

Steady state maximum concentration with low-fat meal conditions at the 400 mg once daily dose was found to be 2.1 ± 1.1 μg/mL. It is recommended; the apparent volume of distribution for venetoclax is 256–321 L. It is bound to human plasma protein. Within a concentration range of 1-30 μM, the fraction unbound in plasma was less than 0.01. Venetoclax is metabolized by CYP3A4/5; those using the drug should not consume grapefruit products. Additionally, while using venetoclax it is not recommended to use other drugs which contain CYP3A inhibitors. Venetoclax is excreted from the body via the fecal route. In 2015, the United States Food and Drug Administration granted the breakthrough therapy designation to venetoclax for people with CLL or SLL who have relapsed, become intolerant to, or refractory to previous treatment. In 2016, the FDA approved venetoclax for use in those with CLL who have 17p deletion and who have been treated with at least one prior therapy. Based on overall response rate, the indication was approved under accelerated FDA approval.

In October 2016 a European Medicines Agency committee recommended conditional marketing approval for venetoclax for CLL in the presence of 17p deletion or TP53 mutation. On June 8, 2018, the Food and Drug Administration granted regular approval to venetoclax for people with CLL or small lymphocytic lymphoma, with or without 17p deletion, who have received at least one prior therapy. On May 15, 2019, the label has hence been extended by accelerated approval to include all adults with CLL/SLL disregarding prior treatment or mutation status. AbbVie Inc. of North Chicago Illinois manufactures Venclexta. It is marketed by both Abbvie and Genentech USA, a member of the Roche Group. AbbVie and Genentech are both commercializing the drug within the United States, but only AbbVie has rights to do so outside of the U. S. According to Reuters 2016 Drugs to Watch, the 2020 forecast sales for Venetoclax are 1.48 billion. Competition as well as potential for combination is expected from other drugs such as ibrutinib and idelalisib, both of which were approved in 2014 to treat CLL.

Venclexta is patented by AbbVie Inc. As of 2016 venetoclax had been tested to treat other hematological cancers, including non-Hodgkin’s lymphoma, multiple myeloma, diffuse large B-cell lymphoma and follicular lymphoma

While You Weren't Looking

While You Weren't Looking is a 2015 South African drama film directed by Catherine Stewart. The film examines the struggles experienced by lesbians living in suburban South Africa compared to those living in townships. 20 years after the end of apartheid and Terri are a mixed-race lesbian couple living in one of the most affluent suburbs of Cape Town. Their adopted daughter, 18, is of mixed racial heritage. Dez and Terri are being torn apart by their marital insecurities, while facing social pressure to "be normal" and "fit in", in spite of the wide range of LGBT rights guaranteed by the post-apartheid regime. Asanda, is caught up in exploring her own sexuality, wavering between her boyfriend Greg, queer "Tommy boy" Shado; the family housekeeper, from the same township as Shado, makes it clear that she is unwelcome in the upper-class neighborhood. Conversely, Asanda's first visit to the township makes her feel she isn't "black enough"; the developing relationship between Asanda and Shado forces Dez and Terri to confront their own prejudices.

The film includes various takes on race and gender politics, from the personal stories of the protagonists, to the passionate voice of a university lecturer, to the images projected in the film. Subplots bring the suburban lesbians' lives into harsh contrast with the lives of queer women in the township. Camilla Waldman – Terri Sandi Schultz – Dez Fezile Mpela – Joe Thulo Lionel Newton – Mack Petronella Tshuma – Asanda Thishiwe Ziqubu – Shado Tina Jaxa – Milly Thulo Jill Levenberg – Yasmin Terence Bridgett – Tiny Pascual Wakefield – Greg The film was shot in and around Cape Town over 24 days, is an Out in Africa Gay and Lesbian Film Festival production; the film received funding by the National Lottery Distribution Trust Fund and additional support from the Department of Trade and Industry, as well as a small grant from The Other Foundation. The film's international premiere took place at the Miami Gay and Lesbian Film Festival on May 2, 2015, the South African premiere was at the Durban International Film Festival on July 20th of the same year.

The original cut of the film is 104 minutes, but a shortened version of 74 minutes was released. The film was an official selection of multiple international film festivals, including: Durban International Film Festival Miami Gay & Lesbian Film Festival Frameline39 San Francisco International LGBTQ Film Festival Torino Gay & Lesbian Film Festival Pan African Film Festival Outfest LA New York African Film Festival Cinema Queer Stockholm Utah Film Center Hamburg International Lesbian & Gay Film Festival Palm Springs International Film Festival Berlin Feminist Film Week Online magazine Spling! gave the film a "satisfactory" 6 out of 10 stars, positively citing the strong local talent, the incorporation of local music and art, the beautiful photography. The review opined that the theme of LGBTQ acceptance, as expounded upon by the academic lecture featured in the film, is too disconnected from the narrative itself, that each subplot was complex enough to warrant a vehicle of its own; the Back Row's review was harsher regarding the same issues, quoting "lovelorn gay lecturer Mack"'s cry that "If you can ‘queer’ gender, you can ‘queer’ anything" as the noble thesis of the film, calling for broadmindedness and acceptance in order for South Africa to move forward, but condemns it as failing to match its vision with artistry, instead featuring clumsy dialogue and artificial performances.

Sharon Calingasan's FilmDoo review, on the other hand, found the film "compelling" and lauded it for taking on the larger issues of the LGBTQ community in South Africa, while celebrating "individuality and humanity in its truest sense." The GLIFF review of the film found the approach to dealing with LGBT, class and racial relations deft and sensitive, reviewer Don Simpson felt that the "interjections from a queer theory class provides While You Weren’t Looking with an intellectualism that cleverly compliments and comments upon the narrative." Official website While You Weren't Looking on IMDb

21st Anniversary: Not That Innocent

21st Anniversary: Not That Innocent is the ninth studio album by British heavy metal band, released on Communiqué Records in 2002. The production of the album lasted for a prolonged time and it was released when lead guitarist Kelly Johnson and bassist Tracey Lamb had left the band, they were replaced by new lead guitarist Jackie Chambers and by the original bass player Enid Williams, who play in two new songs included in this album. All tracks are written except where noted. Kim McAuliffe – lead vocals on tracks 2, 6, 9, 10, 11, 12, rhythm guitar, backing vocals Kelly Johnson – lead vocals on tracks 3, 4, 5, 7, 8, 13, lead guitar on tracks 2-11, 13 Jackie Chambers – lead guitar on tracks 1 and 12 Tracey Lamb – bass on tracks 2-11, backing vocals Enid Williams – lead vocals on track 1, bass on tracks 1 and 12 Denise Dufort – drums Tim Hamill – bass on track 13, producer and engineer Official Girlschool discography