The African Union Mission in Sudan (AMIS) was an African Union (AU) peacekeeping force operating primarily in the country's western region of Darfur to perform peacekeeping operations related to the Darfur conflict. It was founded in 2004, with a force of 150 troops. By mid-2005, its numbers were increased to about 7,000. Under United Nations Security Council Resolution 1564, AMIS was to "closely and continuously liaise and coordinate ... at all levels" its work with the United Nations Mission in Sudan (UNMIS). AMIS was the only external military force in Sudan's Darfur region until UNAMID was established. It was not able to effectively contain the violence in Darfur. A more sizable, better equipped UN peacekeeping force was originally proposed for September 2006, but due to Sudanese government opposition, it was not implemented at that time. AMIS' mandate was extended repeatedly throughout 2006, while the situation in Darfur continued to escalate, until AMIS was replaced by UNAMID on 31 December 2007.

The War in Darfur, also nicknamed the Land Cruiser War, was a major armed conflict in the Darfur region of Sudan that began in February 2003 when the Sudan Liberation Movement (SLM) and the Justice and Equality Movement (JEM) rebel groups began fighting against the government of Sudan, which they accused of oppressing Darfur's non-Arab population. The government responded to attacks by carrying out a campaign of ethnic cleansing against Darfur's non-Arabs. This resulted in the death of hundreds of thousands of civilians and the indictment of Sudan's president, Omar al-Bashir, for genocide, war crimes, and crimes against humanity by the International Criminal Court.