Agadez Mosque is a prominent mosque in Agadez, Tchirozerine Department, Niger. It was made of clay and is the tallest mud-brick structure in the world. The Agadez mosque is the most prominent religious center located in the central part of the Republic of the Niger, and has been a place of worship for centuries.

Agadez, formerly spelled Agadès, is the fifth largest city in Niger, with a population of 110,497 based on the 2012 census. The capital of Agadez Region, it lies in the Sahara desert, and is also the capital of Aïr, one of the traditional Tuareg–Berber federations. The historic centre of the town has been designated a World Heritage Site by UNESCO.