The second season of the American television series Agents of S.H.I.E.L.D., based on the Marvel Comics organization S.H.I.E.L.D., follows Phil Coulson and his team of S.H.I.E.L.D. agents and allies as they attempt to rebuild the organization after it was revealed to have been infiltrated by Hydra in the film Captain America: The Winter Soldier (2014). The season is set in the Marvel Cinematic Universe (MCU) and acknowledges the continuity of the franchise's films and other television series. It was produced by ABC Studios, Marvel Television, and Mutant Enemy Productions, with Jed Whedon, Maurissa Tancharoen, and Jeffrey Bell serving as showrunners.

Marvel's Agents of S.H.I.E.L.D. is an American television series created by Joss Whedon, Jed Whedon, and Maurissa Tancharoen for ABC based on the Marvel Comics organization S.H.I.E.L.D., a peacekeeping and spy agency in a world of superheroes. The series was the first to be set in the Marvel Cinematic Universe (MCU), and it acknowledges the continuity of the franchise's films and other television series. It was produced by ABC Studios, Marvel Television, and Mutant Enemy Productions, with Jed Whedon, Maurissa Tancharoen, and Jeffrey Bell serving as showrunners.