Agkistrodon piscivorus is a species of venomous snake, a pit viper in the subfamily Crotalinae of the family Viperidae. It is one of the world's few semiaquatic vipers, and is native to the Southeastern United States. As an adult, it is large and capable of delivering a painful and potentially fatal bite. When threatened, it may respond by coiling its body and displaying its fangs. Individuals may bite when feeling threatened or being handled in any way. It tends to be found in or near water, particularly in slow-moving and shallow lakes, streams, and marshes. It is a capable swimmer, and like several species of snakes, is known to occasionally enter bays and estuaries and swim between barrier islands and the mainland.

Agkistrodon is a genus of venomous pit vipers commonly known as American moccasins. The genus is endemic to North America, ranging from the Southern United States to northern Costa Rica. Eight species are currently recognized, all of them monotypic and closely related. Common names include: cottonmouths, copperheads, and cantils.