Ahoskie is a town in Hertford County, North Carolina, United States. The population was 5,039 at the 2010 census. Ahoskie is located in North Carolina's Inner Banks region. Its nickname is "The Only One" because no other town in the world is known by the same name. The etymology of the word Ahoskie, which was originally spelled "Ahotsky", was from the Wyanoke Indians, who entered the Hertford County area at the beginning of European settlement.

Robert Lee Vann was an African American newspaper publisher and editor. He was the publisher and editor of the Pittsburgh Courier from 1910 until his death.