Ahoskie is a town in Hertford County, North Carolina, United States. The population was 5,039 at the 2010 census. Ahoskie is located in North Carolina's Inner Banks region. Its nickname is "The Only One" because no other town in the world is known by the same name. The etymology of the word Ahoskie, which was originally spelled "Ahotsky", was from the Wyanoke Indians, who entered the Hertford County area at the beginning of European settlement.

Hertford County is a county located in the U.S. state of North Carolina. As of the 2020 census, the population was 21,552. Its county seat is Winton. It is classified within the region known in the 21st century as the Inner Banks.