The Air Force Global Strike Command (AFGSC) is a Major Command (MAJCOM) of the United States Air Force, headquartered at Barksdale Air Force Base, Louisiana. AFGSC provides combat-ready forces to conduct strategic nuclear deterrence and global strike operations in support of combatant commanders. Air Force Global Strike Command is the Air Force's service component to the United States Strategic Command (USSTRATCOM).

The United States Air Force (USAF) is the air service branch of the United States Armed Forces, and is one of the eight uniformed services of the United States. Originally created on 1 August 1907, as a part of the United States Army Signal Corps, the USAF was established as a separate branch of the United States Armed Forces in 1947 with the enactment of the National Security Act of 1947. It is the second youngest branch of the United States Armed Forces and the fourth in order of precedence. The United States Air Force articulates its core missions as air supremacy, global integrated intelligence, surveillance and reconnaissance, rapid global mobility, global strike, and command and control.