Akani Simbine is a South African sprinter specialising in the 100 metres event. He was fifth at the 2016 Summer Olympics in the men's 100 metres and was the 100 metres African record holder with a time of 9.84 seconds set in July 2021 until broken by Ferdinand Omanyala in September 2021.

The men's 100 metres event at the 2016 Summer Olympics took place between 13–14 August at the Olympic Stadium. 84 athletes from 57 nations competed.