Akhisar is a municipality and district of Manisa Province, Turkey. Its area is 1,645 km2, and its population is 177,419 (2022). It is the site of the ancient city of Thyatira.

Manisa Province is a province and metropolitan municipality in western Turkey. Its area is 13,339 km2, and its population is 1,468,279 (2022). Its neighboring provinces are İzmir to the west, Aydın to the south, Denizli to the southeast, Uşak to the east, Kütahya to the northeast, and Balıkesir to the north. The city of Manisa is the seat and capital of the province. The traffic code is 45.