Al-Mada'in was an ancient metropolis situated on the Tigris in what is now Iraq. It was located between the ancient royal centers of Ctesiphon and Seleucia, and was founded by the Sasanian Empire. The city's name was used by Arabs as a synonym for the Sasanian capital of Ctesiphon, in a tradition that continued after the Arab conquest of Iran.

Ctesiphon was an ancient Iranian city, located on the eastern bank of the Tigris, and about 35 kilometres (22 mi) southeast of present-day Baghdad. Ctesiphon served as a royal capital of the Iranian empire in the Parthian and Sasanian eras for over eight hundred years. Ctesiphon was capital of the Sasanian Empire from 226–637 until the Muslim conquest of Persia in 651 AD.