State Route 52 (SR 52) is an 82.805-mile-long (133.262 km) state highway in the southeastern part of the U.S. state of Alabama. The western terminus of the highway is at an intersection with U.S. Route 331 (US 331) at Opp. The eastern terminus of the highway is at the Georgia state line east of Columbia, where the highway crosses over the Chattahoochee River and enter Hilton, Georgia as Georgia State Route 62.

U.S. Route 331 is a spur of U.S. Route 31. It currently runs for 150 miles (240 km) from Santa Rosa Beach, Florida east of Fort Walton Beach at US 98 to Montgomery, Alabama at US 80 and US 82. Unlike US 131, US 231, and US 431, US 331 never intersects with its "parent" route, US 31; however, the two routes do come within 4 miles (6.4 km) of each other in Montgomery.