State Route 73 (SR 73), is a 11.219-mile-long (18.055 km) state highway in the U.S. state of Alabama. The southern terminus of the highway is at an intersection with SR 71 in Higdon north to the Tennessee state line, where it becomes Tennessee State Route 377 (SR 377). SR 73 travels through rural areas in eastern Jackson County, serving the community of Bryant.

Jackson County is the northeasternmost county in the U.S. state of Alabama. As of the 2020 census, the population was 52,579. The county seat is Scottsboro. The county was named for Andrew Jackson, general in the United States Army and afterward President of the United States of America. Jackson County is a prohibition or dry county, but three cities within the county are "wet", allowing alcohol sales. Jackson County comprises the Scottsboro, AL Micropolitan Statistical Area, and Jackson county is included in the Scottsboro-Fort Payne combined statistical areas. It is the site of Russell Cave National Monument, an archeological site with evidence of 8,000 years of human occupation in the Southeast.