Albert Wesker is a character in Resident Evil, a survival horror video game series created by the Japanese company Capcom. He was first introduced in the original Resident Evil (1996) as the captain of the headquarters Raccoon Police Department's Special Tactics And Rescue Service (S.T.A.R.S.) unit. Wesker has been one of the series' main antagonists as a member of the pharmaceutical conglomerate Umbrella Corporation, the primary antagonistic faction, manipulating story events behind-the-scenes. To further his own plans, Wesker betrays his allies, fakes his death, gains superhuman abilities, and works with both Umbrella's mysterious rival company and their successors in the field of biological weapons development until his ultimate defeat by Chris Redfield and Sheva Alomar in Resident Evil 5 (2009).

Resident Evil, or Biohazard in Japan and parts of Southeast Asia, is a Japanese horror game series and media franchise created by Capcom. It consists of survival horror, third-person shooter and first-person shooter games, with players typically surviving in environments inhabited by zombies and other frightening creatures. The franchise has expanded into other media, including a live-action film series, animated films, television series, comic books, novels, audio dramas and merchandise. Resident Evil is the highest-grossing horror franchise.