Many Native Americans in the United States have been harmed by, or become addicted to, drinking alcohol. Among contemporary Native Americans and Alaska Natives, 11.7% of all deaths are related to alcohol. By comparison, about 5.9% of global deaths are attributable to alcohol consumption. Because of negative stereotypes and biases based on race and social class, generalizations and myths abound around the topic of Native American alcohol misuse.

Little Turtle was a Sagamore (chief) of the Miami people, who became one of the most famous Native American military leaders. Historian Wiley Sword calls him "perhaps the most capable Indian leader then in the Northwest Territory," although he later signed several treaties ceding land, which caused him to lose his leader status during the battles which became a prelude to the War of 1812. In the 1790s, Mihšihkinaahkwa led a confederation of native warriors to several major victories against U.S. forces in the Northwest Indian Wars, sometimes called "Little Turtle's War", particularly St. Clair's defeat in 1791, wherein the confederation defeated General Arthur St. Clair, who lost 900 men in the most decisive loss by the U.S. Army against Native American forces.