Alex Vause is a fictional character played by Laura Prepon on the Netflix series Orange Is the New Black. The character is loosely based on the real ex-girlfriend of Piper Kerman, author of Orange Is the New Black: My Year in a Women's Prison. Before her arrest, Vause worked for an international drug cartel and was in a relationship with protagonist Piper Chapman, who once transported drug money for her during their travels. Vause is portrayed as the catalyst for Chapman's indictment. She is reunited with her ex-lover in federal prison, nearly a decade after the events that led to their breakup. Her relationship with Chapman is reignited, as they carry out a tumultuous love affair in prison. Vause is noted for her pragmatism, forthrightness, wit and veiled vulnerability. She is a main character in seasons one, three, four, five, six, and seven and a recurring character in season two.

Laura Prepon is an American actress. She rose to fame with her role as Donna Pinciotti in the Fox sitcom That '70s Show (1998–2006). She is also known for portraying Alex Vause in the Netflix comedy-drama series Orange Is the New Black (2013–2019). Prepon made her film debut in 2001 with the independent drama Southlander. Her other films include the romantic drama Come Early Morning (2006), the comedy Lay the Favorite (2012), the thriller The Girl on the Train (2016), and the drama The Hero (2017).