The Alexander Romance, once described as "antiquity's most successful novel", is an account of the life and exploits of Alexander the Great. The Romance describes Alexander the Great from his birth, to his succession of the throne of Macedon, his conquests including that of the Persian Empire, and finally his death. Although constructed around an historical core, the romance is mostly fantastical, including many miraculous tales and encounters with mythical creatures such as sirens or centaurs. In this context, the term Romance refers not to the meaning of the word in modern times but in the Old French sense of a novel or roman, a "lengthy prose narrative of a complex and fictional character".

Alexander III of Macedon, most commonly known as Alexander the Great, was a king of the ancient Greek kingdom of Macedon. He succeeded his father Philip II to the throne in 336 BC at the age of 20 and spent most of his ruling years conducting a lengthy military campaign throughout Western Asia, Central Asia, parts of South Asia, and Egypt. By the age of 30, he had created one of the largest empires in history, stretching from Greece to northwestern India. He was undefeated in battle and is widely considered to be one of history's greatest and most successful military commanders.