The Alexander Valley is a Californian American Viticultural Area (AVA) just north of Healdsburg in Sonoma County. It is home to many wineries and vineyards, as well as the city of Cloverdale. It is the largest and most fully planted wine region in Sonoma. Highway 101 runs through the valley, and the Russian River flows down the valley, surrounded by vineyards on both sides. From the higher elevations of the valley rim, there is a view as far south as Taylor Mountain and Sonoma Mountain. The region was named for Cyrus Alexander, owner of a part of the Rancho Sotoyome Mexican land grant, in 1847. Granted AVA status in 1984, the boundaries of the appellation are defined in the Code of Federal Regulations, Title 27, Section 9.53.

California wine production has a rich viticulture history since 1680 when Spanish Jesuit missionaries planted Vitis vinifera vines native to the Mediterranean region in their established missions to produce wine for religious services. In the 1770s, Spanish missionaries continued the practice under the direction of the Father Junípero Serra who planted California's first vineyard at Mission San Juan Capistrano.