The Alfa Romeo C42 is a Formula One car designed and built by Alfa Romeo to compete in the 2022 Formula One World Championship. The C42 is built to the new generation of technical regulations, originally intended for introduction in 2021.

The 2022 FIA Formula One World Championship was a motor racing championship for Formula One cars, which was the 73rd running of the Formula One World Championship. It is recognised by the Fédération Internationale de l'Automobile (FIA), the governing body of international motorsport, as the highest class of competition for open-wheel racing cars. The championship was contested over twenty-two Grands Prix, which were held around the world, and ended earlier than in recent years to avoid overlapping with the FIFA World Cup.