The All-American Canal is an 82-mile (132 km) long aqueduct, located in southeastern California. It conveys water from the Colorado River into the Yuma Project, the Imperial Valley, and to nine cities. It is the Imperial Valley's only water source, and replaced the Alamo Canal, which was located mostly in Mexico. The Imperial Dam, about 30 miles (48 km) northeast of Yuma, Arizona on the Colorado River, diverts water into the All-American Canal, which runs to just west of Calexico, California before its last branch heads mostly north into the Imperial Valley. Smaller canals branching off the All-American Canal move water into the Yuma Valley and the Imperial Valley. These canal systems irrigate up to 630,000 acres (250,000 ha) of crop land and have made possible a greatly increased crop yield in this area, originally one of the driest on earth. It is the largest irrigation canal in the world, carrying a maximum of 26,155 cubic feet per second (740.6 m3/s). Agricultural runoff from the All-American Canal drains into the Salton Sea.

The Colorado River is one of the principal rivers in the Southwestern United States and in northern Mexico. The 1,450-mile-long (2,330 km) river, the 5th longest in the United States, drains an expansive, arid watershed that encompasses parts of seven U.S. states and two Mexican states. The name Colorado derives from the Spanish language for "colored reddish" due to its heavy silt load. Starting in the central Rocky Mountains of Colorado, it flows generally southwest across the Colorado Plateau and through the Grand Canyon before reaching Lake Mead on the Arizona–Nevada border, where it turns south toward the international border. After entering Mexico, the Colorado approaches the mostly dry Colorado River Delta at the tip of the Gulf of California between Baja California and Sonora.