Alphonse and Gaston is an American comic strip by Frederick Burr Opper, featuring a bumbling pair of Frenchmen with a penchant for politeness. It first appeared in William Randolph Hearst's newspaper, the New York Journal on September 22, 1901, with the title "Alphonse a la Carte and His Friend Gaston de Table d'Hote". The strip was later distributed by King Features Syndicate.

Frederick Burr Opper was one of the pioneers of American newspaper comic strips, best known for his comic strip Happy Hooligan. His comic characters were featured in magazine gag cartoons, covers, political cartoons and comic strips for six decades.