Altus is a city in Franklin County, Arkansas, United States. Located within the Arkansas River Valley at the edge of the Ozark Mountains, the city is within the Fort Smith metropolitan area. The epicenter of the Altus American Viticultural Area (AVA) within Arkansas Wine Country, the city is home to four wineries. Although founded as a coal mining community, the wine industry has driven the Altus economy since the first vineyards were planted in 1872. The population was 758 at the 2010 census, down from 817 at the 2000 census. In 2020, the population was 669 and was estimated as unchanged in 2021 and 2022.

Franklin County is a county in Arkansas. As of the 2020 census, the population was 17,097. The county has two county seats, Charleston and Ozark. The county was formed on December 19, 1837, and named for Benjamin Franklin, American statesman. Franklin County is a damp county, with alcohol sales allowed except in Prairie & Alix townships, and limits on liquor sales in the city of Branch.