The Mpondomise people, also called Ama-Mpondomise, are a Xhosa-speaking people. Their traditional homeland has been in the contemporary era Eastern Cape province of South Africa, during apartheid they were located both in the Ciskei and Transkei region. Like other separate Xhosa-speaking kingdoms such as Aba-Thembu and Ama-Mpondo, they speak Xhosa and are at times considered as part of the Xhosa people.

The Mpondo People or simply Ama-Mpondo, is one of the kingdoms in what is now the Eastern Cape. Having been established way back in 1226. The Ama-Mpondo Nation were first ruled by its founder who was King Mpondo kaNjanya who lived around and later the 'Ama-Nyawuza'clan, by nationality referred to themselves as 'Ama-Mpondo'. They are related to other Aba-Mbo kingdoms and chiefdoms in South Africa.