Amargosa Valley is an unincorporated town located on U.S. Route 95 in Nye County, in the U.S. state of Nevada.

U.S. Route 95 is a major U.S. highway traversing the U.S. state of Nevada from north to south directly through Las Vegas and providing connections to both Carson City and Reno. US 95 is cosigned with Interstate 80 for 95 miles (153 km) between a junction in Trinity and Winnemucca before heading north into Oregon at McDermitt. At 646.71 miles (1,040.78 km), it is the longest highway in Nevada.