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Amati

Amati is the last name of a family of Italian violin makers who lived at Cremona from about 1538 to 1740. Their importance is considered equal to those of the Bergonzi and Stradivari families. Today, violins created by Nicolò Amati are valued at around $600,000; because of their age and rarity, Amati instruments are kept in museum or private collections and are played in public. Andrea Amati designed and created the violin and cello known as the "violin family", he standardized the basic form, size and method of construction. Makers from nearby Brescia experimented, such as Gasparo da Salò, Micheli and Pellegrino, but it was Andrea Amati in Cremona, who gave the modern violin family their definitive profile; the first violin was ordered by Lorenzo de' Medici in 1555. His letter to Amati stated the instrument was to be "made of the highest quality materials like that of a lute, but simple to play". What became of this first violin is not known. A number of his instruments survived for some time, dating between 1538 and 1574.

The largest number these are from 1560, a set for an entire orchestra of 38 ordered by Catherine de Médicis the regent queen of France and bore hand painted royal French decorations in gold including the motto and coat of arms of her son Charles IX of France. Of these 38 instruments ordered, Amati created violins of two sizes, violas of two sizes and large-sized cellos, they were in use until only 14 of these instruments survived. His work is marked by selection of the finest materials, great elegance in execution, soft clear amber, soft translucent varnish, an in depth use of acoustic and geometrical principles in design. Andrea Amati was succeeded by his sons Antonio Girolamo Amati. "The Brothers Amati", as they were known, implemented far-reaching innovations in design, including the perfection of the shape of the f-holes. They are thought to have pioneered the modern alto format of viola, in contrast to older tenor violas, but the widespread belief that they were the first ones to do so is incorrect given that Gasparo da Salo made violas ranging from altos of 39 cm to tenors of 44.7 cm.

Nicolò Amati was the son of Girolamo Amati. He was the most eminent of the family, he improved the model adopted by the rest of the Amatis and produced instruments capable of yielding greater power of tone. His pattern was unusually small, but he made a wider model now known as the "Grand Amati", which have become his most sought-after violins. Of his pupils, the most famous were Antonio Stradivari and Andrea Guarneri, the first of the Guarneri family of violin makers; the last maker of the family was Nicolò's son, Girolamo Amati, known as Hieronymus II. He improved the arching of his father's instruments. Instruments in the UK include Andrea Amati violins from the set delivered to Charles IX of France in 1564. Amati instruments at the Ashmolean Museum, Oxford. Andrea Amati Violin, 1564 Viola Amati instruments at the Royal Academy of Music Museum, London Amati instrument at the Tullie House Museum and Art Gallery, Carlisle Andrea Amati Violin, 1564 Amati instruments at the National Music Museum: Andrea Amati: "The King", circa 1545, the world's oldest extant cello Viola, 1560 Violin, 1560 Violin, 1574 Girolamo Amati: Double bass, 1680 Violin, 1604 Violin, 7/8-size, 1609 Violino piccolo, 1613 Nicolò Amati: Violin, 1628 Amati instruments at the Metropolitan Museum of Art Andrea Amati: Violin, c. 1560 Nicolò Amati: Violin, 1669 Patrick O'Brian's fictional British sea captain Jack Aubrey is described as owning a "fiddle far above his station, an Amati no less", in The Surgeon's Mate.

In the Wine-Dark Sea, book fifteen of the series, Stephen Maturin now has a Girolamo Amati and Aubrey a Guarneri. In Satyajit Ray's short story Bosepukure Khoonkharapi, the fictional detective Feluda deduces that a character was murdered because he owned an Amati violin. In the manga and anime series Gunslinger Girl, Henrietta carries an Amati violin case, it contains a Fabrique Nationale P90. On the radio show, Yours Truly, Johnny Dollar, the January 1956 episode "The Ricardo Amerigo Matter" centered on a stolen Amati violin. Antonio Stradivari Amati Quartet Dom Nicolò Amati, Italian luthier not part of this family but who adopted this surname Luthier San Maurizio, Venice Dilworth, John, "The Violin and Bow-Origins and Development" in: The Cambridge Companion to the Violin, ed. Robin Stowell. Cambridge: Cambridge University Press, pp. 1–29. Andrea Amati: Violin, Heilbrunn Timeline of Art History, The Metropolitan Museum of Art Instruments of the Amati family on the online database MIMO, website mimo-international.com

İsmet İnönü Boulevard

İsmet İnönü Boulevard is a major avenue in Mersin, Turkey. It is named after İsmet İnönü, the second president of Turkish Republic between 1938 and 1950; the eastern end of the boulevard is to the north of the Mersin Harbor, where it meets the state highway D.400 at about 36°48′46″N 34°39′18″E. It runs parallel to the Mediterranean Sea coast line to south west for about 4.5 km within the second-level municipality of Akdeniz. The Atatürk Park is between the sea; the governor's office, mayor's office, Mersin Grand Mosque Atatürk Manument and Mersin Halkevi are situated to the north of the boulevard. It continues within Yenişehir second-level municipality; the Tevfik Sırrı Gür Stadium is to the north of the boulevard and Mersin Lighthouse is to the south. At the junction with Adnan Menderes Boulevard, it turns to northwest and runs perpendicular to the sea coast, its total course in Yenişehir municipality is about 6.7 km. In this course, it intersects with Gazi Mustafa Kemal Boulevard by an interchange.

The Nevin Yanıt Athletics Complex and the Macit Özcan Sports Complex are situated on the north portion of the boulevard. Up to 1950s, the first 4.5 km of the boulevard was the coast line. During the construction of the harbor the dredged material of the sea basin was spread out in front of the city to build the boulevard and Atatürk Park. Rest of the boulevard was constructed after the 1980s. Wowturkey for images

Richard and Mary Parker

Richard Parker and Mary Parker are fictional characters appearing in American comic books published by Marvel Comics. They are the parents of the superhero known as Spider-Man. Richard and Mary Parker were created by Larry Lieber. For many years prior to The Amazing Spider-Man Annual #5, there had been no explanation of why Peter Parker was being raised by his aunt and uncle, with his parents only appearing in flashbacks and photographs; that issue answered the question: Richard and Mary Parker were murdered by Albert Malik, one of Johann Schmidt's successors to the persona of Red Skull. In The Amazing Spider-Man #365, Spider-Man's 30th anniversary, they reappeared. Two years however, in #388, they were revealed to be Life Model Decoys created by the Chameleon and were destroyed. In the novel Mary Jane, it is said they died in a plane accident while going to Switzerland to turn in some important discovery that Richard made. Peter tries to figure out what the discovery was but fails, as he cannot figure out the things Richard has written on his board.

In July 1997, Untold Tales of Spider-Man #-1, part of Marvel Comics' "Flashback Month" event, written by Roger Stern and drawn by John Romita, Sr. the characters origins are expanded. Since they have been mentioned. Captain Richard Parker, a decorated soldier of the United States Army Special Forces, was recruited by Nick Fury to the C. I. A. Mary Fitzpatrick was the daughter of O. S. S. Agent "Wild Will" Fitzpatrick, she attended the best schools and followed in her father's footsteps, becoming a C. I. A. Translator and data analyst. Richard and Mary met on the job, fell in love, married, they eloped having a more elaborate service, fooling many. Mary became a field agent like Richard, they were assigned to investigate Baroness Adelicia Von Krupp, who had captured an agent of a "friendly power". They rescued Logan from Baron Wolfgang von Strucker. After that mission, they discovered, they are believed to be the parents of Teresa Parker, who followed in their footsteps as a CIA agent, but her relation to them to has not been confirmed.

Their son, was left in the care of Richard's older brother and his wife, when Richard and Mary were away on missions. While on a mission to investigate Albert Malik, the third Red Skull, they posed as traitors and double agents to infiltrate his criminal organization in Algeria being discovered. Malik had an assassin kill the two by causing it to crash, they were subsequently declared missing in action/presumed dead, as two burnt bodies were found in the remains. Richard and Mary's son, grew up to become Spider-Man. Although he has only vague memories of his parents and no memory of their militaristic history, his aunt and uncle share photographs and happy memories with him, but not their belief that they had been traitors to their country; when Peter discovers this, he travels to Algeria. He finds Malik. Spider-Man turns the Finisher's missile against him, killing him, but not before revealing that Richard and Mary were in fact innocent. Spider-Man clears his parents' names. Years the Chameleon, working for Harry Osborn, created Life Model Decoys of Richard and Mary.

These LMDs were near-perfect robotic replicas of Peter's dead parents, managed to convince him that they had in fact been held captive overseas for most of his life. Aunt May retained some suspicions, as there were some things they did not know, such as Richard and Mary's elopement; when Peter discovers that they were fake, he suffers a nervous breakdown. However, when the decoys were ordered to attack Parker, the Mary duplicate - sharing the original's love for her son - saves him instead. Neither LMD survives the incident. After battling the Chameleon, Spider-Man discovers that Harry Osborn was behind the whole thing, as an effort to avenge his dead father, Norman Osborn. Spider-Man becomes mentally unhinged over time, until having a near-death experience. May Parker learns the truth about the Life Model Decoys, via learning the truth about Spider-Man. May draws strength by talking to the graves of Mary and Ben about Peter's life; the cynical mindset of Harry Osborn and the Chameleon was present in the LMDs during Maximum Carnage: When Aunt May advises Peter to "listen to your heart", "Richard" tells a different lesson: Strip away the veneer of society and civilization and you'll find a devil inside all men....

That prison was overrun with Peter. Sadistic evil men who'd do anything—no matter how twisted, how immoral—to break a man down. Destroy his soul... Oh, sure there are good men in the world. Your uncle Ben was one of them, and look where it got him. Dead. Shot down like a dog, and knowing my brother, he was looking up at the scum who did it—trying to understand why. But when it comes to the devils, Peter—there is no why. No rhyme or reason.... Use whatever means possible to stop the madness—before it swallows you up.... When Shriek uses her psychic powers to turn the whole town against Spider-Man and the other super-heroes, "Richard" remarks that the "moral, orderly" world he remembered while in prison "was just an illusion! The evil was here—all along—festering beneath the surface!"—inviting a sharp rebuke from Peter's

2018 Hungarian Grand Prix

The 2018 Hungarian Grand Prix was a Formula One motor race held on 29 July 2018 at the Hungaroring in Mogyoród, Hungary. The race was the 12th round of the 2018 Formula One World Championship and marked the 34th running of the Hungarian Grand Prix, the 33rd time the race had been run as a World Championship event since the inaugural season in 1950. Mercedes driver Lewis Hamilton entered the round with a 17-point lead over Sebastian Vettel in the Drivers' Championship, extended it to 24 points. In the World Constructors' Championship, Mercedes led Ferrari by 8 points before the race, they further extended their lead to 10 points; the Ferrari crew wore black armbands in honour of former Ferrari chairman Sergio Marchionne, who died following complications from surgery on 25 July 2018. Black stripes were incorporated into the cars of Ferrari as well as engine customer teams Haas and Sauber in tribute to Marchionne. Hamilton got away well with Bottas in close pursuit. Max Verstappen retired on lap 5 following an engine failure, with a brief virtual safety car period to remove his car.

Hamilton pitted from the lead on lap 25, however Vettel stayed out and didn't make his pit stop until lap 39, was unable to get out ahead of Bottas. By lap 65, Vettel and Räikkönen had caught up to Bottas on fresher tyres. Vettel went for an overtake at turn 2 and moved into second place, but Bottas made contact trying to defend, damaging his front wing and letting Räikkönen through. Three laps Daniel Ricciardo attempted an overtake on Bottas, but the two drivers made contact and picked up damage. Bottas gave the position up on the final lap, he was handed a 10-second time penalty for causing a collision, however this did not change his finishing position. Hamilton won the race, with Räikkönen finishing in third. Notes^1 – Lance Stroll was required to start from the pit lane after changing his front wing. Notes^1 – Valtteri Bottas received a 10-second time penalty for causing a collision with Daniel Ricciardo. Note: Only the top five positions are included for both sets of standings. 2018 Hungaroring FIA Formula 2 round

Jairo Ramos Gizzi

Jairo Ramos Gizzi is a Venezuela-born Italian baseball first baseman. Ramos throws left-handed, he plays for the T & A San Marino club of the Italian Baseball League. As a member of the Italy national baseball team, Ramos competed in the 2004 Summer Olympics and won the 2010 European Baseball Championship. Ramos, who debuted in the Italian League with Grosseto BBC in 1998, connected his 100th home run in the circuit during the 2013 season, as well as his 1,000th hit in 2014. In between, Ramos played winter ball for the Leones del Caracas, Cardenales de Lara, Tiburones de La Guaira and Pastora de los Llanos clubs of the Venezuelan Professional Baseball League in a span of 19 seasons from 1989–2007, he represented Venezuela in the 2006 Caribbean Series

Metabolite Set Enrichment Analysis

Metabolite Set Enrichment Analysis is a method designed to help metabolomics researchers identify and interpret patterns of metabolite concentration changes in a biologically meaningful way. It is conceptually similar to another used tool developed for transcriptomics called Gene Set Enrichment Analysis or GSEA. GSEA uses a collection of predefined gene sets to rank the lists of genes obtained from gene chip studies. By using this “prior knowledge” about gene sets researchers are able to identify significant and coordinated changes in gene expression data while at the same time gaining some biological context. MSEA does the same thing by using a collection of predefined metabolite pathways and disease states obtained from the Human Metabolome Database. MSEA is offered as a service both through a stand-alone web server and as part of a larger metabolomics analysis suite called MetaboAnalyst; the MSEA web server is a available web server for performing metabolite set enrichment analysis on human or mammalian metabolomics data.

The required input is either a list of compound names and concentrations. The output is a set of graphs and tables with embedded hyperlinks to the pertinent pathway images and descriptors; the Metabolite Set Enrichment Analysis offered by the web server is based on a curated library of more 5000 predefined metabolite sets covering various human metabolic pathways, hundreds of human disease states, human biofluid and tissue locations as well as human SNP-metabolite associations. MSEA allows users to upload custom metabolite sets for more specialized analysis. Three different enrichment analyses are supported by the server: 1) overrepresentation analysis. ORA analysis only needs a list of compound names. SSP and QEA need their concentrations. Workflows and other screenshot tutorials on how to use the server are available on the MSEA website; the MSEA server offers a number of other functions including the conversion between metabolite common names and major database identifiers. In 2011 MSEA functions were integrated into MetaboAnalyst.

This integration allows users to perform a more complete analysis and to link to other data processing and data interpretation functions available in MetaboAnalyst. MSEA is offered in the MeltDB software platform. MetaboAnalyst MetPA Metabolome Metabolomics