Amelia Mary Earhart was an American aviation pioneer and author. Earhart was the first female aviator to fly solo across the Atlantic Ocean, she set many other records, wrote best-selling books about her flying experiences, was instrumental in the formation of The Ninety-Nines, an organization for female pilots. Born in Atchison, Earhart developed a passion for adventure at a young age gaining flying experience from her twenties. In 1928, Earhart became the first female passenger to cross the Atlantic by airplane, for which she achieved celebrity status. In 1932, piloting a Lockheed Vega 5B, Earhart made a nonstop solo transatlantic flight, becoming the first woman to achieve such a feat, she received the United States Distinguished Flying Cross for this accomplishment. In 1935, Earhart became a visiting faculty member at Purdue University as an advisor to aeronautical engineering and a career counselor to women students, she was a member of the National Woman's Party and an early supporter of the Equal Rights Amendment.
During an attempt to make a circumnavigational flight of the globe in 1937 in a Purdue-funded Lockheed Model 10-E Electra and navigator Fred Noonan disappeared over the central Pacific Ocean near Howland Island. Earhart was the daughter of Samuel "Edwin" Stanton Earhart and Amelia "Amy", she was born in Atchison, Kansas, in the home of her maternal grandfather, Alfred Gideon Otis, a former federal judge, the president of the Atchison Savings Bank and a leading citizen in the town. Amelia was the second child of the marriage, after an infant was stillborn in August 1896, she was of part German descent. Alfred Otis had not favored the marriage and was not satisfied with Edwin's progress as a lawyer. According to family custom, Earhart was named after her two grandmothers, Amelia Josephine Harres and Mary Wells Patton. From an early age, Amelia was the ringleader while her sister Grace Muriel Earhart, two years her junior, acted as the dutiful follower. Amelia was nicknamed "Meeley" and Grace was nicknamed "Pidge".
Their upbringing was unconventional since Amy Earhart did not believe in molding her children into "nice little girls". Meanwhile their maternal grandmother disapproved of the "bloomers" worn by Amy's children and although Earhart liked the freedom they provided, she was aware other girls in the neighborhood did not wear them. A spirit of adventure seemed to abide in the Earhart children, with the pair setting off daily to explore their neighborhood; as a child, Earhart spent long hours playing with sister Pidge, climbing trees, hunting rats with a rifle and "belly-slamming" her sled downhill. Although the love of the outdoors and "rough-and-tumble" play was common to many youngsters, some biographers have characterized the young Earhart as a tomboy; the girls kept "worms, katydids and a tree toad" in a growing collection gathered in their outings. In 1904, with the help of her uncle, she cobbled together a home-made ramp fashioned after a roller coaster she had seen on a trip to St. Louis and secured the ramp to the roof of the family toolshed.
Earhart's well-documented first flight ended dramatically. She emerged from the broken wooden box that had served as a sled with a bruised lip, torn dress and a "sensation of exhilaration", she exclaimed, "Oh, Pidge, it's just like flying!"Although there had been some missteps in Edwin Earhart's career up to that point, in 1907 his job as a claims officer for the Rock Island Railroad led to a transfer to Des Moines, Iowa. The next year, at the age of 10, Earhart saw her first aircraft at the Iowa State Fair in Des Moines, her father tried to interest her sister in taking a flight. One look at the rickety "flivver" was enough for Earhart, who promptly asked if they could go back to the merry-go-round, she described the biplane as "a thing of rusty wire and wood and not at all interesting". The two sisters and Muriel, remained with their grandparents in Atchison, while their parents moved into new, smaller quarters in Des Moines. During this period, Earhart received a form of home-schooling together with her sister, from her mother and a governess.
She recounted that she was "exceedingly fond of reading" and spent countless hours in the large family library. In 1909, when the family was reunited in Des Moines, the Earhart children were enrolled in public school for the first time with Amelia Earhart entering the seventh grade at the age of 12 years. While the family's finances improved with the acquisition of a new house and the hiring of two servants, it soon became apparent that Edwin was an alcoholic. Five years in 1914, he was forced to retire and although he attempted to rehabilitate himself through treatment, he was never reinstated at the Rock Island Railroad. At about this time, Earhart's grandmother Amelia Otis died leaving a substantial estate that placed her daughter's share in a trust, fearing that Edwin's drinking would drain the funds; the Otis house was auctioned along with all of its contents. In 1915, after a long search, Earhart's father found work as a clerk at the Great Northern Railway in St. Paul, where Earhart entered Central High School as a junior.
Edwin applied for a transfer to Springfield, Missouri, in 1915, but the current claims officer reconsidered his retirement and demanded his job back, leaving the elder Earhart with nowhere to go. Facing another calamitous move, Amy Earhart took her children to C
Zieria lasiocaulis known as Willi Willi zieria, is a rare species of flowering plant in the citrus family Rutaceae and is endemic to New South Wales. It is a tall shrub or small tree with three-part leaves and inconspicuous white flowers, found only at high altitudes in areas with a high rainfall. Zieria lasiocaulis is a tall shrub or small tree which grows to a height of 6 m and has branches which are dotted with oil glands and which are scented when bruised. Younger branches are covered with fine hairs; the leaves are composed of three leaflets with the central one elliptic to lance-shaped with the narrower end towards the base, 40–60 mm long and 15–22 mm wide with a petiole 17–21 mm long. The leaves are more or less glabrous but scented when crushed; the flowers are arranged in large groups, the groups shorter than the leaves. The sepals are triangular, about 1 mm long and the four petals are white, about 4 mm long, overlap at their bases and are covered with soft hairs. Flowering occurs from late autumn to spring and the fruits which follow in summer are glabrous and dotted with oil glands.
Zieria lasiocaulis was first formally described in 2002 by Jim Armstrong and the description was published in Australian Systematic Botany from a specimen collected on Mount Banda Banda. According to Armstrong, the specific epithet is derived from Greek lasio meaning "hairy" and caulis, meaning "stem", referring to the long, simple hairs on the younger branches; the ancient Greek word "hairy" is lasios and the word for "stem" is kaulos. Caulis is the Latin word for "stem". Willi Willi zieria grows on rocky cliffs and on rainforest margins in the Willi Willi National Park, Werrikimbe National Park and New England National Park; this zieria is classified as "endangered" under the New South Wales Threatened Species Conservation Act and the Commonwealth Government Environment Protection and Biodiversity Conservation Act 1999 Act. The main threat to the species is inappropriate fire regimes
MiR-206 is a microRNA that in humans is a member of the myomiR family which includes miR-1, miR-133, miR-208a/b among few others. As well as being regulated during the embryonic development of skeletal muscle, miR-206 is regulated by estradiol. C2C12 myoblast cells are used as a model for the study of cell differentiation in skeletal muscle. Furthermore, miR-206 is expressed in triple-negative breast tumors that grow independent of estradiol, miR-206 is a predictor of worse overall survival in breast cancer patients; the biogenesis of miR-206 is unique in that the primary mature transcript is generated from the 3p arm of the precursor hairpin rather than the 5p arm. MiR-206 has 12 additional family members, whereby the seed sequence is 100% conserved across all miRNAs within the family. Single nucleotide polymorphisms are present in the miRNA sequence, some of them with functional consequences, in the sense that the efficiency of miRNA binding to a cognate mRNA target is altered depending on a single nucleotide substitution.
In fact a number of studies have indicated that the canonical seed sequence of a miRNA is not longer the sole determinate in miRNA:mRNA pairing interactions, as mutations of residues outside the seed region alters binding efficacy. MiR-206 is of interest due to the continued detection of this miRNA in samples from those with type 2 diabetes and non-alcoholic fatty liver disease. In some studies the therapeutic delivery of miR-206 in a dietary obese mouse model resulted in reduced lipid and glucose production within the liver; the ability of miR-206 to facilitate insulin signaling and modulate lipogenesis indicates miR-206 may be a novel therapy for those with hyperglycemia