The tenth season of American Dad! aired on Fox from September 29, 2013, to May 18, 2014. This is the final full season on Fox, as the next season is a mini-season featuring three unaired episodes that Fox quickly aired, in order for the network to end the show.

American Dad! is an American animated sitcom created by Seth MacFarlane, Mike Barker and Matt Weitzman for the Fox Broadcasting Company. The series was moved to TBS in 2014 and continues to air new episodes to this day. American Dad! is the first television series made to premiere on Fox's Animation Domination block. The series premiered on February 6, 2005, following Super Bowl XXXIX, with the rest of the first season airing three months later beginning May 1, 2005.