The American Federation of Musicians of the United States and Canada (AFM/AFofM) is a 501(c)(5) labor union representing professional instrumental musicians in the United States and Canada. The AFM, which has its headquarters in New York City, is led by president Tino Gagliardi. Founded in Cincinnati in 1896 as the successor to the National League of Musicians, the AFM is the largest organization in the world to represent professional musicians. It negotiates fair agreements, protects ownership of recorded music, secures benefits such as healthcare and pension, and lobbies legislators. In the US, it is known as the American Federation of Musicians (AFM), and in Canada, it is known as the Canadian Federation of Musicians/Fédération Canadienne des Musiciens (CFM/FCM).

The American Federation of Labor was a national federation of labor unions in the United States that continues today as the AFL–CIO. It was founded in Columbus, Ohio, in 1886 by an alliance of craft unions eager to provide mutual support and disappointed in the Knights of Labor. Samuel Gompers was elected the full-time president at its founding convention and was re-elected every year except one until his death in 1924. He became the major spokesperson for the union movement.