The second season of the American horror anthology television series American Horror Story, subtitled Asylum, takes place in 1964 and follows the stories of the staff and inmates who occupy the fictional mental institution Briarcliff Manor, and intercuts with events in the past and present. The ensemble cast includes Zachary Quinto, Joseph Fiennes, Sarah Paulson, Evan Peters, Lily Rabe, Lizzie Brocheré, Dylan McDermott, James Cromwell and Jessica Lange, with all returning from the first season, except newcomers Fiennes, Brocheré, and Cromwell. The season marks the first to not feature cast mainstays Connie Britton, Taissa Farmiga and Denis O'Hare.

Zachary John Quinto is an American actor and film producer. He is known for his roles as Sylar, the primary antagonist from the science fiction drama series Heroes (2006–2010); Spock in the film Star Trek (2009) and its sequels Star Trek Into Darkness (2013) and Star Trek Beyond (2016); Charlie Manx in the AMC series NOS4A2, and Dr. Oliver Thredson in American Horror Story: Asylum, for which he received a nomination for an Emmy award. His other starring film roles include Margin Call (2011), Hitman: Agent 47 (2015), Snowden (2016), and Hotel Artemis (2018). He also appeared in smaller roles on television series, such as So Notorious, The Slap, and 24, and on stage in Angels in America, The Glass Menagerie, and Smokefall.