The American Indian Wars, also known as the American Frontier Wars, and the Indian Wars, was a conflict initially fought by European colonial empires, and later on by the Confederate states of America, Republic of Texas, Mexico and the United States of America against various American Indian tribes in North America. These conflicts occurred from the time of the earliest colonial settlements in the 17th century until the end of the 19th century. The various wars resulted from a wide variety of factors, the most common being the desire of settlers and governments for Indian tribes' lands. The European powers and their colonies enlisted allied Indian tribes to help them conduct warfare against each other's colonial settlements. After the American Revolution, many conflicts were local to specific states or regions and frequently involved disputes over land use; some entailed cycles of violent reprisal.

The United States of America, commonly known as the United States or America, is a country primarily located in North America. It is a federation of 50 states, a federal capital district, and 326 Indian reservations. Outside the union of states, it asserts sovereignty over five major unincorporated island territories and various uninhabited islands. The country has the world's third-largest land area, second-largest exclusive economic zone, and third-largest population, exceeding 334 million.