American Vampire is an American comic book series created by writer Scott Snyder and drawn by artist Rafael Albuquerque. It was published by DC Comics under its Vertigo imprint. American Vampire continued under the newly-created DC Black Label imprint after Vertigo was closed in January 2020. The series imagines vampires as a population made up of many different secret species, and charts moments of vampire evolution and inter-species conflict throughout history. The focus of the series is a new American bloodline of vampires, born in the American West in the late 19th century. The first of this new species is a notorious outlaw named Skinner Sweet, who wakes from death, after being infected, to find he has become a new kind of vampire, something stronger and faster than what came before, impervious to sunlight, with a new set of strengths and weaknesses. The series goes on to track his movements through various decades of American history—along with the movements of his first and only known progeny: Pearl Jones, a young woman working as a struggling actress in the 1920s silent film industry when she is attacked by a coven of European vampires hiding in Hollywood. Sweet saves her (uncharacteristically) by giving her his blood, thereby turning her into an American vampire like him, at which point she seeks revenge on the classic vampires who attacked her in life. The complicated and charged relationship Jones has with Sweet is another focus of the series. The first five issues featured two stories—one by Snyder and the other by Stephen King, both drawn by Rafael Albuquerque. With the sixth issue, Scott Snyder took over as sole writer. The original series ran from 2010–2013 and lasted 34 issues. A second series called American Vampire: Second Cycle ran from 2014–2015 and lasted 11 issues and the third and final series called American Vampire: 1976 ran from December 2020 – October 2021 and lasted 10 issues.

Scott Snyder is an American comic book author. He is known for his 2006 short story collection Voodoo Heart, and his work for DC Comics, including series such as American Vampire, Detective Comics, a highly acclaimed run on Batman, Swamp Thing, and Justice League as well as the company-wide crossover storylines "Dark Nights: Metal" and "Dark Nights: Death Metal." He has also written creator-owned comics published through Image Comics, including Wytches, Undiscovered Country, and Nocterra.