The American hog-nosed skunk is a species of hog-nosed skunk from Central and North America, and is one of the largest skunks in the world, growing to lengths of up to 2.7 feet (82 cm). Recent work has concluded the western hog-nosed skunk is the same species, and Conepatus leuconotus is the correct name of the merged populations.

Skunks are mammals in the family Mephitidae. They are known for their ability to spray a liquid with a strong, unpleasant scent from their anal glands. Different species of skunk vary in appearance from black-and-white to brown, cream or ginger colored, but all have warning coloration.