Ames is a city in Story County, Iowa, United States, located approximately 30 miles (48 km) north of Des Moines in central Iowa. It is best known as the home of Iowa State University (ISU), with leading agriculture, design, engineering, and veterinary medicine colleges. A United States Department of Energy national laboratory, Ames Laboratory, is located on the ISU campus.

Story County is a county in the U.S. state of Iowa. As of the 2020 census, the population was 98,537, making it the ninth-most populous county in Iowa. The county seat is Nevada; the largest city is Ames. The geographical center of Iowa lies in Story County, 5 miles (8.0 km) northeast of Ames.