Amfilochia is a town and a municipality in the northwestern part of Aetolia-Acarnania in Greece, on the site of ancient Amfilochia. Under the Ottoman Empire, it was known as Karvasaras.

Aetolia-Acarnania is one of the regional units of Greece. It is part of the geographic region of Central Greece and the administrative region of West Greece. A combination of the historical regions of Aetolia and Acarnania, it is the country's largest regional unit. Its capital is Missolonghi for historical reasons, with its biggest city and economic centre at Agrinio. The area is now connected with the Peloponnese peninsula via the Rio-Antirio Bridge. The surrounding regional units take in Arta in Epirus, a narrow length bordering Karditsa of Thessaly, Evrytania to the northeast, and Phocis to the east.