Amherst Center is a census-designated place (CDP) in the City of Amherst in Hampshire County, Massachusetts, United States. The CDP covers the primary village in town. The population was 19,065 at the 2010 census, out of a total town population of 37,819. It is part of the Springfield, Massachusetts Metropolitan Statistical Area.

Amherst is a city in Hampshire County, Massachusetts, United States, in the Connecticut River valley. Amherst has a council–manager form of government, and is considered a city under Massachusetts state law. Amherst is one of several Massachusetts municipalities that have city forms of government but retain "The Town of" in their official names. At the 2020 census, the population was 39,263, making it the highest populated municipality in Hampshire County. The town is home to Amherst College, Hampshire College, and the University of Massachusetts Amherst, three of the Five Colleges.