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Amor Vincit Omnia (Caravaggio)

Amor Vincit Omnia is a painting by the Italian Baroque artist Caravaggio. Amor Vincit Omnia shows Amor, the Roman Cupid, wearing dark eagle wings, half-sitting on or climbing down from what appears to be a table. Scattered around are the emblems of all human endeavours – violin and lute, coronet and compasses, pen and manuscript, bay leaves, flower and trampled under Cupid's foot; the painting illustrates the line from Virgil's Eclogues X.69, Omnia vincit amor et nos cedamus amori. A musical manuscript on the floor shows a large "V", it has therefore been suggested that the picture is a coded reference to the attainments of Marchese Vincenzo Giustiniani: his Genoese family ruled Chios in 1622, hence the coronet. The symbology thus holds the possible reading: Vincenzo Conquers All. Giustiniani is said to have prized it above all other works in his collection; the subject was common for the age. Caravaggio's treatment is remarkable for the realism of his Cupid – where other depictions, such as a contemporary Sleeping Cupid by Battistello Caracciolo, show an idealised generic, beautiful boy, Caravaggio's Cupid is individual, charming but not at all beautiful, all crooked teeth and crooked grin: one feels that one would recognise him in the street.

The shock of the Caravaggio, quite apart from the dramatic chiaroscuro lighting and the photographic clarity, is the mingling of the allegorical and the real, this sense it gives of a child, having a good time dressing up in stage-prop wings with a bunch of arrows and having his picture painted. Despite the clear indications of Caravaggio's practice of painting direct from a live model, there is an undeniable resemblance to the pose of Michelangelo's Victory now in the Palazzo Vecchio, it is the artist had this in mind; the painter Orazio Gentileschi lent Caravaggio the wings as props to be used in the painting, this allows precise dating of 1602–3. It was an immediate success in the circles of Rome's cultural elite. A poet wrote three madrigals about it, another wrote a Latin epigram in which it was first coupled with the Virgilian phrase Omnia Vincit Amor, although this did not become its title until the critic Giovanni Pietro Bellori wrote his life of Caravaggio in 1672. Much scholarly and non-scholarly ink has been spilled over the alleged eroticism of the painting.

Yet the homoerotic content was not so apparent to Giustiniani's generation as it has become today. Naked boys could be seen on any riverbank or seashore, the eroticisation of children is much a cultural artefact of the present-day rather than Caravaggio's; the story that the Marchese kept Amor hidden behind a curtain relates to his reported wish that it should be kept as a final pièce de résistance for visitors, to be seen only when the rest of the collection had been viewed – in other words, the curtain was to reveal the painting, not to hide it.. The challenge is to see the Amor Vincit through 17th century eyes. In 1602, shortly after Amor Vincit was completed, Cardinal Benedetto Giustiniani, Vincenzo's brother and collaborator in the creation of the Giustiniani collection of contemporary art, commissioned a painting from the noted artist Giovanni Baglione. Baglione's Divine and Profane Love showed Divine Love separating a juvenile Cupid on the ground in the lower right corner from a Lucifer in the left corner.

Its style was derivative of Caravaggio and a clear challenge to the recent Amor, the younger painter bitterly protested at what he saw as the plagiarism. Taunted by one of Caravaggio's friends, Baglione responded with a second version, in which the devil was given Caravaggio's face, thus began a long and vicious quarrel, to have unforeseeable ramifications for Caravaggio decades after his death when the unforgiving Baglione became his first biographer. Sandrart described Amor as "A life size Cupid after a boy of about twelve... has large brown eagle's wings, drawn so and with such strong colouring and relief that it all comes to life.". Richard Symonds, an English visitor to Rome about 1649/51, recorded the Cupid as being "ye body and face of his owne boy or servant thait laid with him"; the Italian art historian Giani Pappi has put forward the theory that this Cecco may be identical with Cecco del Caravaggio, a notable Italian follower of Caravaggio who emerged in the decade after the master's death.

While this remains controversial, there is more widespread support for Pappi's further proposal that Cecco del Caravaggio should be identified as an artist known as Francesco Boneri. Cecco Boneri, if this is his name, appears in many of Caravaggio's paintings, as the juvenile angel supporting Christ in The Conversion of Saint Paul as the angel offering a martyr's palm to the saint in The Martyrdom of Saint Matthew, as the young Isaac about to have his throat cut in The Sacrifice of Is

Heather Moore

Heather Moore is an engineer from Michigan known for her research in construction management and construction productivity. She is the Vice President of Operations at MCA, she studied Industrial and Operations Engineering at the University of Michigan, holds an MBA from the University of Michigan-Flint, obtained a Ph. D in Construction Management at the Michigan State University, her Ph. D. research focused with specific application in construction. Her papers and research have been used in innovation in construction development, she has co-authored two books on improving productivity on construction job sites and has published many articles in specialized magazines, including work referencing both MCA’s experience in Agile Construction and the ASTM standard in combination with information entropy. She has contributed to other books and research work conducted at MCA on topics of productivity and process design. Heather has written two books with Perry Daneshgari focused on productivity in construction, has written articles in magazines like Construction Executive, IEC Insights Magazine, ASTM, Electrical Construction & Management Magazine among others blogs and pages.

She has conducted research for New Horizons Foundation. Besides her academic research for the University of Michigan, she is now Vice President of Operations for MCA but has been Manager of Research and Assistant Implementer. Before MCA she worked for John E. Green Company. Competing in the New Construction Environment A Compilation to Lead the Way - Book 1: The Here and Now-How to Be Competitive. Application of ASTM E2691 Standard Practice for Job Productivity Measurement in Agile Construction Operational Model Needed to Compete in Industrialized Construction - Industrialization of Construction, A Compilation to Lead the Way, Book 2: Industrialization of Construction, A Compilation to Lead the Way and Future, Dealing with the Challenges of More Work, Book 3: Efficiency and Continuous Improvement: Survival of the Unfits - Book 4: Heather Moore Profile

RGD motif

The tripeptide Arg-Gly-Asp consists of Arginine and Aspartate. It was identified as the amino acid sequence within the extracellular matrix protein fibronectin that mediates cell attachment; the RGD cell binding sequence has since been identified in other extracellular matrix proteins, including vitronectin and laminin. The family of membrane proteins known as integrins act as receptors for these cell adhesion molecules via the RGD motif. A subset of the integrins recognize the RGD motif within their ligands, the binding of which mediates both cell-substratum and cell-cell interactions; these integrins include αvβ3, α5β1 and αIIbβ3. The RGD domain is both indispensable for cell membrane binding; as such, the RGD cell binding motif has supreme relevance in the fields of oncology, tissue engineering and regenerative medicine. Because of their cell-adhesive activity, RGD peptides are incorporated into biomaterials designed to promote wound healing. RGD is an important peptide sequence used in Targeted therapy.

For example, the RGD peptide can be used to target cancer cells on which cell membrane integrins are up-regulated compared to healthy cells. Though the minimum sequence peptide RGD retains the property of cell adhesion, integrin-RGD bonds are weaker than integrin-fibronectin bonds; the reduced adhesion strength is due to both lack of secondary structure and other synergistic domains, namely PHSRN, present in the full-length protein. Furthermore, full length protein domains differentially mediate cell morphology, cell migration and cell proliferation compared to RGD alone. Other minimum sequence motifs have been identified, including the GFOGER 30 amino acid sequence from collagen 1 and the YGISR and A5G81 sequences from laminin

Margaret Sullivan (journalist)

Margaret M. Sullivan is an American journalist, the media columnist for The Washington Post, she was the first woman to hold the position. In that role, she reported directly to Arthur Sulzberger, Jr. as the "readers' representative". She began her tenure on September 1, 2012, joining The New York Times from The Buffalo News, where she had been editor and vice-president, her first column in The Washington Post ran on May 22, 2016. Sullivan is a native of New York and a graduate of Georgetown University, she holds an M. S. J. from Northwestern University’s Medill School of Journalism. Sullivan was appointed to the Pulitzer Prize Board in 2011 and has been a juror several times and has served as the chairwoman of the commentary jury in 2006, she has been elected a director of the American Society of News Editors and led its First Amendment committee. Sullivan was the first woman to serve as the editor and as the managing editor of The Buffalo News, the largest newspaper in Western New York, after working as a reporter and columnist.

Sullivan focused The Buffalo News's reporting on poverty, economic development and inequities in public education as well as establishing its first investigative team. In The New York Times announcement on July 16, 2012, former executive editor Jill Abramson said, “Margaret has the right experience to assume this critical role for us at this time, she has an impressive 32-year background in print journalism where she has distinguished herself as a reporter, columnist and manager. And critically for us at this time, she has shown adeptness at embracing new platforms and engaging and interacting with readers in real time online, in print and in person.” Unlike previous public editors of The New York Times, Sullivan signed on for four years. In December 2015, Sullivan announced. Sullivan stated that "The role requires an outsider's perspective, so I've thought all along that having a clear time limit serves The Times and its readers best."Her tenure was celebrated by both journalists and readers.

"Her tenure accomplished many things, most the potential of web-based media reporting and criticism to combat the media establishment’s groupthink," Eric Alterman observed. In February 2016, it was announced that when Sullivan left The Times, she would be joining The Washington Post as its media columnist. Arthur Sulzberger Jr; the Times’s publisher praised Sullivan in a memo to staff stating that she had “ushered the position into a new age.” Her first column in The Washington Post ran on May 22, 2016

Raj Chakraborty

Raj Chakraborty is an Indian film director and producer. A person from middle-class family background, he was born in West Bengal, he graduated from Naihati. He is one of the most commercially successful film-makers in Tollywood. Before directing his debut film, he was busy in Bengali TV. Raj Chakraborty was associated with Zee Bangla's popular laughter show Mirakkel, hosted by Mir, dance competition Dance Bangla Dance, judged by Mithun Chakraborty, during their initial days, he directed Star Jalsha's laughter programme I Laugh You. Raj Chakraborty produced the television serial Kanamachi, aired on Star Jalsha. For Zee Bangla, Raj Chakraborty Productions made the popular soap opera Raage Anuraage, he returned as director of his own show I Laugh you, a show he had started in its first season. I Laugh You was a popular laughter programme in the Indian regional television world, aired on Star Jalsha. Raj Chakraborty's association with another popular Bengali entertainment channel Colors Bangla occurred with him producing the soap opera Kajallata for that channel.

Raj Chakraborty on IMDb

Innovative Medicines Initiative

The Innovative Medicines Initiative is a European initiative to improve the competitive situation of the European Union in the field of pharmaceutical research. The IMI is a joint initiative of the DG Research of the European Commission, representing the European Communities, the European Federation of Pharmaceutical Industries and Associations. IMI is laid out as a Joint Technology Initiative within the Seventh Framework Programme. Michel Goldman was the first executive director, from September 2009 until December 2014; the Innovative Medicines Initiative is aimed towards removing research bottlenecks in the current drug development process. The IMI Joint Technology Initiative, to be implemented by the IMI Joint Undertaking is meant to address these research bottlenecks, its €2bn budget makes it the largest biomedical public-private partnership in the world. The funding scheme has been criticised, requiring universities to invest more money than with EU FP7 programs. Besides the non-competitive financial aspects of participation in IMI projects for academia, this criticism discusses that intellectual property is flowing to industry.

The Sixth Framework Programme's research projects InnoMed AddNeuroMed and InnoMed PredTox acted as pilot projects establishing the feasibility of this particular public-private partnership. Since the IMI has had four funding rounds: the first call had the topic Safety, while the second call was about Efficacy. Projects for these two calls are ongoing; the IMI 2 will run until 2024, while the IMI 1 is still running. Overall budget is taken for half from the European Horizon 2020 program. Goals of that second calls are to improve clinical trials success rate, deliver clinical proof of concept and new medicines. In September 2014 IMI-TRAIN, an IMI/ENSO-funded education and training collaboration to support biomedical scientists and professionals, has been launched. IMI-TRAIN will serve as a collaboration platform for the IMI-funded education and training projects: EMTRAIN: European Medicines Research Training Network Eu2P: European programme in Pharmacovigilance and Pharmacoepidemiology Pharmatrain: Pharmaceutical Medicine Training Programme SafeSciMET: Safety Sciences Modular Education and Training International Labour Organization World Intellectual Property Organization Official website