Amy Seimetz is an American actress and filmmaker. She has appeared in several productions, including AMC's The Killing, HBO's Family Tree, and films like Upstream Color, Alien: Covenant, Pet Sematary, and No Sudden Move.

Upstream Color is a 2013 American experimental science fiction film written, directed, produced by, and starring Shane Carruth. The film is the second feature directed by Carruth, following his 2004 debut Primer. It stars Amy Seimetz, Carruth, Andrew Sensenig, and Thiago Martins.