Amyl nitrite is a chemical compound with the formula C5H11ONO. A variety of isomers are known, but they all feature an amyl group attached to the nitrite functional group. The alkyl group is unreactive and the chemical and biological properties are mainly due to the nitrite group. Like other alkyl nitrites, amyl nitrite is bioactive in mammals, being a vasodilator, which is the basis of its use as a prescription medicine. As an inhalant, it also has a psychoactive effect, which has led to its recreational use, with its smell being described as that of old socks or dirty feet. It was first documented in 1844 and came into medical use in 1867.

Amyl and the Sniffers are an Australian pub rock and punk rock band based in Melbourne, consisting of vocalist Amy Taylor, drummer Bryce Wilson, guitarist Declan Martens, and bassist Gus Romer. At the ARIA Music Awards of 2019, their self-titled debut record won the Best Rock Album category.