An American Tragedy is an opera in two acts composed by Tobias Picker, with a libretto by Gene Scheer. This was Picker's fourth opera, written four years after the debut of Thérèse Raquin. Based on the 1925 Theodore Dreiser novel, An American Tragedy, the opera was commissioned by the Metropolitan Opera, and premiered in New York City on December 2, 2005.

Tobias Picker is an American composer, pianist, and conductor, noted for his orchestral works Old and Lost Rivers, Keys To The City, and The Encantadas, as well as his operas Emmeline, Fantastic Mr. Fox, An American Tragedy and Lili Elbe, among many other works.