An American Werewolf in London is a 1981 comedy horror film written and directed by John Landis. An international co-production of the United Kingdom and the United States, the film stars David Naughton, Jenny Agutter, Griffin Dunne and John Woodvine. The title is a cross between An American in Paris and Werewolf of London. The film's plot follows two American backpackers, David and Jack, who are attacked by a werewolf while travelling in England, causing David to become a werewolf under the next full moon.

Comedy horror, also known as horror comedy, is a literary, television, and film genre that combines elements of comedy and horror fiction. Comedy horror has been described as able to be categorized under three types: "black comedy, parody and spoof." It often crosses over with the black comedy genre. Comedy horror can also parody or subtly spoof horror clichés as its main source of humour or use those elements to take a story in a different direction. Examples of comedy horror films include Abbott and Costello Meet Frankenstein (1948), An American Werewolf in London (1981), the Evil Dead franchise (1981–present), Gremlins (1984), Shaun of the Dead (2004), and The Cabin in the Woods (2011).